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The amino acid sequences of the glutamate dehydrogenase mutants are as shown in SEQ ID NO

Using both in vitro (hemin-induced ferroptosis in cultured neurons) and in vivo (collagenase-induced intracerebral hemorrhage in mice) models, the researchers illustrated that NAC effectively prevented hemin-induced ferroptotic cell death in cultured neurons and, when administered post-injury in mice, significantly reduced neuronal loss while enhancing functional recovery

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