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Description
Among the three thioredoxin reductase isoenzymes known in mammals, TXNRD3 is the only one that contains an additional N-terminal glutaredoxin domain, which enables this isoenzyme to be involved in both the thioredoxin and the glutaredoxin systems (Arnr, 2009)
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[DOI] [Google Scholar] 58.Yderstraede K.B., Pedersen F.B., Dragsholt C., Trostmann A., Laier E., Larsen H.F

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia