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2022;185:481125.e4817

Non-union fractures and delayed healing often reflect underlying metabolic issues (vitamin D deficiency, inadequate dietary calcium, chronic glucocorticoid use) that peptide administration cannot override

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At the severe end of this spectrum, persistent energy deficiency may lead to functional hypothalamic amenorrhea (FHA), characterized by suppression of GnRH pulsatility and consequent disruption of ovulatory function, representing a reversible but clinically significant manifestation of energy-conserving neuroendocrine adaptation [90]