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After ligand binding, the activated IGF-1 or insulin receptor phosphorylates several intracellular substrates, including IR substrates (IRS) and the Src-homology-2-domain containing transforming protein (Shc)
Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity
Sphingosine 1-phosphate liposomes for targeted nitric oxide delivery to mediate anticancer effects against brain glioma tumors
Goddard DR, Berry M, Butt AM
