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For instance, experimental studies that involve glutathione (Yamasoba et al., Figure 2 Consistent with this idea, glutathione, a tripeptide molecule (cysteine, glutamic acid, and glycine) and the most abundant endogenous free radical scavenger in humans, was the first antioxidant evaluated for the treatment of NIHL (Yamasoba et al., N-acetylcysteine (NAC), a cysteine precursor, is an antioxidant molecule that enhances the production of glutathione (Kopke et al., a replenisher of this endogenous scavenger (Kopke et al., Interestingly, recent evidence suggests that HK-2, a multifunctional antioxidant with a metal chelator and free radical scavenger properties (Kawada and Kador, Several micronutrients such as vitamins A, C, and E show antioxidant properties and have been used either individually or combined as experimental treatments for NIHL