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10.1074/jbc.M115.680090 J

Glutathione encourages its breakdown by acting as a substrate of the enzyme formaldehyde dehydrogenase

PPAR is a member of PPARs, a group of nuclear hormone transcription factors whose presence at key sites involved in pain procession, such as the spinal cord, has been demonstrated as the primary modulator, increasing the expression of anti-inflammatory cytokines (IL-10) and reducing pro-inflammatory cytokines [122]

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