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In HFD-induced mice and PA-treated hepatocytes, knockdown of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) could inhibit the expression of cleaved caspase-3 and cleaved poly ADP-ribose polymerase (PARP), one of the cleavage substrates of caspase, by upregulating the expression of telomerase reverse transcriptase (mTERT), exerting an anti-apoptotic effect

Over the final 7 days, the mice were administered CdCl 2 intraperitoneally on a daily basis in order to expose them to Cd (Figure 1A)

Elevated intraocular pressure promotes mitophagy Our results indicate that glaucomatous conditions can increase mitophagy, as demonstrated by significant increases in mitolysosomes in the Control + OHT mice compared to our control (nave) group