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At physiological levels, BCAAs enhance CD8 + T cell antitumor activity via FoxO1-mediated glucose transporter 1 (GLUT1) upregulation, facilitating glycolytic-oxidative phosphorylation coupling (Yao et al., 2023)

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Following a detailed analysis of the advantages and limitations associated with nose-to-brain delivery, we consolidate recent advances in nasal nano-delivery systems for treating CNS disorders, emphasizing their capacity to improve brain-targeting efficiency, enhance therapeutic efficacy, reduce systemic toxicity, and enable previously undruggable CNS targets

The RDI is approximately 1 mg for both adult men and women [86]