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It serves as the outermost barrier against environmental, microbial, and physical insults

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DD methylation analysis or plasma methionine/SAM/SAH panels reveal: methylation efficiency SAM/SAH ratio methionine sufficiency oxidative stress burden zinc/copper ratios presence of inflammation affecting the methylation cycle Treatment may include: methylcobalamin methylfolate (in appropriate cases) P5P TMG or betaine methionine support zinc correction gentle titration of SAMe Because undermethylation is closely linked to OCD-like presentations, supporting methylation improves OCD and undermethylation symptoms when paired with mitochondrial stabilization

doi: 10.3389/fnmol.2021.742294 Received 16 July 2021 Accepted 23 August 2021 Published 09 September 2021 Volume 14 - 2021 Edited by Jun Hirayama, Komatsu University, Japan Reviewed by Sooyoung Chung, Ewha Womans University, South Korea