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Additionally, metformins influence on nitric oxide (NO) production, poly (ADP-ribose) polymerase 1 (PARP-1) inhibition, and modulation of reactive oxygen species (ROS) and sulfur species further contributes to its multifaceted actions

Immunofluorescence detection of the EMT biomarkers E-cadherin, N-cadherin, vimentin in UM-SCC6 spheroids showed that CAF-S2/S4 sEVs groups significantly decreased E-cadherin expression and significantly increased N-cadherin, vimentin compared with the PBS group

GHK-Cu interacts with collagen expression and extracellular matrix organization

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