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39,40 Fused 1,2,4-triazolium cations (e.g., 14 ) are formed from the cyclization of 10 (R 3 = H) and nitrogen heterocycles, while cyclization with Schiff bases produces 15 (Scheme 6)

Quaranta et al

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44 Additionally, in patients who are already taking some form of oral B 12 supplementation, demonstrating B 12 deficiency can be a challenge, even when symptoms are typical (including those of neuropathy-like paraesthesia and numbness) as serum B 12 concentrations may be just within, or sometimes above, the normal range