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Description
Injectable: Why Its Not a 1:1 Swap Heres the first and most critical concept our team stresses: you absolutely cannot take a dosage protocol for injectable BPC-157 and simply apply it to an oral form
While no specific dietary restrictions will be imposed, recruited patients will be advised to be judicious in the choice of food consumed during the study period to minimise the risk of food poisoning

(13)Fmoc-Pro-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val- (13) Preparation of Fmoc-Pro-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-resin: (12)Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-1050530105010603DMF3DMF2DMFFmoc-Pro-OHDIEATBTU/HOBtHBTU/HOBtBOP/HOBt105010603DMF3DMF2Fmoc-Pro-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val- In the Fmoc-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala-Gly-Leu-Val-resin of step (12), add decapping reagent 1050 React at for 5-30 minutes, drain with a vacuum pump, re-add capping reagent at 10-50C, react for 10-60 minutes, drain, wash with isopropanol for 3 times, DMF for 3 times, and distilled DMF for 2 times , add the mixture of Fmoc-Pro-OH, DIEA, TBTU/HOBt or HBTU/HOBt or BOP/HOBt dissolved in DMF, react at 10-50C for 10-60 minutes, dry with a vacuum pump, and wash with isopropanol for 3 times , washed 3 times with DMF, washed 2 times with DMF steamed, and dried to obtain Fmoc-Pro-Pro-Pro-Gly-Lys(Boc)-Pro-Ala-Asp(otBu)-Asp(otBu)-Ala- Gly-Leu-Val-resin
Institutional Review Board Statement This research was approved by the local Ethics Committee (case number 380-59-10106-17-100/290) and by the Directorate of Veterinary (UP/I-322-01/15-01/22)