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The demonstration of this enzyme decrease in relation to non-structural cardiac arrhythmias and without other explicit pathogenic mechanisms, at ayoung age, allows an appropriate correction (of oxidative stress)

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

However, in the long term, if more and more agents from existing clinically safe drugs are used and proven in clinical applications for health span extension, it is likely that more anti-aging agents from synthetic compounds will emerge in the future

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