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Description
In a typical proteomic analysis of CSF, immunodepletion is performed to remove abundant proteins and reduce the high dynamic range of this biofluid

247 These complex interactions underscore the critical role of mitochondrial function in regulating HIF-mediated responses

For instance, both brain-specific or whole-body SIRT1-overexpressing transgenic mice exhibit a slowed aging and a prolonged lifespan

Konietzko N
