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Additionally, the inflammatory response in asthma increases oxidative stress aggravating the disease

Patients could be included in our analysis more than once if they had a repeat but separate hospital encounter

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Rotenone can freely cross the bloodbrain barrier and is a well-established mitochondrial toxin that specifically inhibits the complex I (NADHdehydrogenase) of the electron transport chain leading to ATP depletion, energy failure and mitochondrial ROS production, which in turn induces cytochrome C release and apoptotic cell death (Clayton et al., 2006