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10.1016/j.ccr.2014.04.005 [DOI] [PMC free article] [PubMed] [Google Scholar] Paiva S
A systematic review of cohort studies"
Studies have shown upregulation of HIF, VEGF, and VEGFR-2 in limb ischemia, especially in acute limb ischemia as opposed to chronic (102, 103)
From our point of view, when this whole system becomes altered-whether obesity, genetics or environmental factors act to disrupt its symphony-insulin resistance, steatosis, MetS, and ultimately T2D may develop
