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Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3

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The proposed mechanisms include activation of the hypothalamicpituitaryadrenal (HPA) axis and the sympathetic nervous system, leading to altered cytokine profiles and immune dysregulation
