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Description
To date, three patterns of p-i-related hypersensitivity reactions have been proposed: the altered peptide model of p-i HLA, the allo-immune model of p-i HLA, and the p-i TCR model ( The altered peptide model of p-i HLA and the allo-immune model of p-i HLA were both developed because some ADRs generated by small molecule drugs are limited exclusively to the HLA allele (36)
Peptides Therapy Dr
(PubMed) Lawson LD, Ransom DK, Hughes BG
doi: 10.1089/jmf.2013.0137
