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Medications and Glucose-6-Phosphate Dehydrogenase Deficiency An Evidence-Based Review Ilan Youngster Lidia Arcavi Renata Schechmaster Yulia Akayzen Hen Popliski Janna Shimonov Svetlana Beig Matitiahu Berkovitch Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect and one of the most common genetic disorders worldwide, with an estimated 400 million people worldwide carrying a mutation in the G6PD gene that causes deficiency of the enzyme