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For example, esculin (25-100 mg/kg) inhibits the TLR4/MyD88 signaling pathway and downregulates the expression of IL-1, IL-6, TNF-, MCP-1 and ICAM-1 in LPS-induced acute kidney injury mice (107)
In addition, the mean bladder weights (as a surrogate for tumor burden) in male mice drinking Rhodiola rosea extract SHR-5 decreased by 69% compared to those who drank normal water [102]

Ghule AE, Kulkarni CP, Bodhankar SL, Pandit VA
In this context, the continued evaluation of these compounds as potential treatments for the negative symptoms of schizophrenia remains a critical priority (Dunayevich et al
