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World J Gastroenterol 28(29):37803792 Liu Y et al (2018) Critical role of FOXO3a in carcinogenesis
doi: 10.1186/s12711-022-00757-z 53 ScandurraG

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The PI3K signaling pathway is dysregulated in many tumors, and analyses have shown that PIK3CA is an oncogene that also contributes to tumor progression partially via metabolic reprogramming 188