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Mechanisms that commonly induce ROS generation in viral infections include the deregulation of mitochondrial function, activation and upregulation of NOX production, and modification of the Nrf2/ARE pathway, with superoxide being the most commonly produced ROS 55

In addition to its role in ATP synthesis, mitochondrial coenzyme Q 10 mediates the oxidation of dihydroorotate to orotate in the de novo pyrimidine synthesis

10.1016/j.chest.2016.07.003 151 PapadopoulosN

Maintenance phase: Once your levels are healthy and symptoms improve, we move to a maintenance schedule, which might be a monthly shot or a return to high-dose oral supplements if your absorption allows