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Last, the accelerated titration designs described by Simon and colleagues42 provided three different designs for intrapatient dose escalation until a doselimiting toxicity is observed, after which the design switches to the traditional 3+3 design with 40% dosestep increments

This can cause tissue damage and oxidative stress

The study also demonstrated that BPC-157 promoted VEGF expression in wounded skin tissues, confirming the angiogenic mechanism operates in chemical burn injuries similar to other wound types

[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Bonnet S., Paulin R., Sutendra G., Dromparis P., Roy M., Watson K.O., Nagendran J., Haromy A., Dyck J.R.B., Michelakis E.D