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There is evidence that alterations in the GH/IGF-1 axis contribute to this scenario, at least in the early stages
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update. Clinical Pharmacology and Therapeutics , vol
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[DOI] [PubMed] [Google Scholar] 275.Berjukov S., Aczel S., Beyer B., Kimball S.D., Dichtl M., Hering S., Striessnig J
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Zhang Y, Jiao Y, Li Z, Tao Y, Yang Y
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