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Description
It has been recognized that exercise training triggers an increase in NO production, Ca 2+ -calmodulin kinase interaction, and adenosine monophosphate-activated protein kinase (AMPK) activation, which leads to PGC1 upregulation and activation in both skeletal and cardiac muscle cells

As such, the possibility and the requirement of a regular supplementation is still a matter of debate [71]

Shera, P., Dhawan, A., & Aneja, A
295 , C1510C1517 (2008)
