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2004 Apr;5(4):43640

For example, HCV induces inflammatory responses by activating IRE1, which interacts with TRAF2 to phosphorylate JNK, leading to activation of inflammation mediators

The tritium labeling sites were located on two prolines

This impairment leads to the accumulation of dysfunctional mitochondria, exacerbating oxidative stress and inflammation [227]
