l-carnitine supplement weight loss effectiveness The bright and the dark sides of supplementation: a systematic review | Journal of the International Society of Sports Nutrition Benefits of L-Carnitine for PCOS:
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Shana E McCormack, Zi Wang, Kristin L Wade, Anna Dedio, Nicolette Cilenti, Julia Crowley, Franziska Plessow, Vaneeta Bamba, Jeffrey D Roizen, Yaoguang Jiang, Jack Stylli, Arjun Ramakrishnan, Michael L Platt, Karuna Shekdar, Michael J Fisher, Victoria L Vetter, Matthew Hocking, Rui Xiao, Elizabeth A Lawson, A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity, Journal of the Endocrine Society, Volume 7, Issue 5, May 2023, bvad037, 28
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Another strategy relies on inhibition of the glycine transporter (sarcosine, bitopertin) or of D-amino acid oxidase (DAAO), the enzyme that metabolizes D-serine (sodium benzoate)
Results on its efficacy are conflicting, with some studies showing positive effect and others showing no effect
