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Conclusion IGF-1 LR3 is a synthetic analogue of natural human insulin-like growth factor 1
This genetic interaction has led to the creation of therapies that target the specific disease pathways influenced by the APOE4 protein (154, 155)

25 In addition, lipofuscin accumulation enhances caspase-3 activity and promotes lysosomal membrane disruption, which is linked to the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome and induction of necroptosis
