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Contraindication screening : Tirzepatide is contraindicated in personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and in patients with severe hypersensitivity to tirzepatide

In severe cases of dehydration, fainting or loss of consciousness can occur
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The exact mechanisms by which LD proteins are targeted for proteasomal degradation remain unclear

doi: 10.1093/oxfordjournals.epirev.a036069