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Genetic and pharmacologic NNMT suppression reduces adiposity and improves metabolic readouts in preclinical models, with supportive cellular data showing increases in NAD and SAM and suppression of lipogenesis

Stimulation of lipolysis and hormone-sensitive lipase via the extracellular signal-regulated kinase pathway

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- People with active or recent cancer history (the trial record contains a small number of cancers in the 12-week oral arm