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The surgical alterations permanently compromise b12 absorption through multiple mechanisms

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excess is renally excreted, though very high levels can cause dermatologic or metabolic effects

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(ML and CC are equivalent measurements) 6

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its activity is diminished in cellular assays owing to its swift degradation to adenosine and Hcy by SAH hydrolase ( Streptomyces , serves as a SAM-mimicking methyltransferase inhibitor

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