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Cancer and its treatment can significantly impact nutritional status, leading to a condition known as cachexia, characterized by muscle wasting and weight loss

Inherited Defects in Folate Metabolizing Enzymes Mutations in the methylene THF reductase gene (MTHFR) are associated with a disorder that was originally referred to as hyperhomocysteinemia

Further clinical trials are needed for a more precise conclusion

That is one of the major reasons for the darkness under your eyes but you may be amazed to know that there are other factors which contribute to dark and puffy under eyes such as genetics, lack of moisture, allergies, bone structure and thin skin