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Description
In summary, rational design has led to the development of two long-acting GLP-1 analogs, liraglutide and semaglutide, that have made a vast contribution to the management of T2D in terms of improvements in glycemic control, body weight, blood pressure, lipids, beta-cell function, and CV outcomes
2010 May;68(5):1059-64
had one batch that took a while to arrive but product quality has never been an issue
The additional electrostatic interactions confer strong binding to SMRT even in the absence of serine phosphorylation and might explain why SHARP SPOC exhibits higher affinity for SMRT/NCoR compared to the CTD
