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some tumors rely on it for survival under high oxidative pressure, while deficiencies in healthy cells might promote tumor initiation through DNA damage

Kussmaul L, Hirst J (2006) The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria

Other studies have suggested that long-term excessive vitamin C intake could be linked with formation of kidney stones

Silibinin improves tumor immunity Silibinin inhibits tumor growth through immunomodulatory activities, such as regulating immune cells (Tregs, macrophages, DCs, NK cell), inhibiting inflammatory cytokines (IFN- , IL-2, IL-6, IL-10, IL-12, TNF- , and TGF- ), and modulating immune check points (PD-L1 and PD-1) [889,890,891,892,893]