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10.1113/jphysiol.2002.018713 13
In childhood-onset patients, the network showed stronger connections between nodes representing disease duration, chronic hyperglycemia, and cognitive functions, suggesting that these factors may contribute to more pronounced cognitive impairments
According to the cholinergic hypothesis, decreasing ACh levels in the brain are the primary cause of cognitive impairment in Alzheimer's disease
They are smaller, more targeted, and in many cases can be administered through multiple routes including topical application, subcutaneous injection, or oral delivery
