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Elevate homocysteine levels, impairing normal blood vessel function, promoting oxidative stress, and increasing risk of atherosclerosis, cardiovascular disease, insulin resistance, and Type 2 diabetes
However, factors like overall health, metabolism, and post-therapy care significantly influence the treatments effectiveness and outcome
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Despite not placing mice on a histamine-free diet, our work defines a key role for endogenous MC-derived histamine in driving phenotypic severity
