glutathione cross blood-brain barrier Crossing the barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery Glutathione metabolism at the bloodâ•'cerebrospinal
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Chen MC, Ling MH, Lai KY, Pramudityo E
This is why a gradual dose titration schedule is standard practice

[DOI] [PMC free article] [PubMed] [Google Scholar] 223.Lindvall O., Brundin P., Widner H., Rehncrona S., Gustavii B., Frackowiak R., Leenders K.L., Sawle G., Rothwell J.C., Marsden C.D., et al

339 The complexes inhibit thioredoxin reductase in mammalian cells and trypanothione reductase in parasites, eliciting potent antileishmanial activity in the low micromolar range across multiple leishmania species via oxidative stress
