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Drugs The pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W

304 Inhibition of FTO effectively alleviates progression of dexamethasone-induced fatty liver in mice

Abbreviations 8-OHDG: 8-hydroxy-deoxyguanosine BCL10: B-cell lymphoma/leukemia 10 CAT: Catalase CL: Corpus luteum CORT: Corticosterone COX2: Cyclo-oxygenase 2 Cu-Zn SOD: Copper-zinc SOD ERK1/2: Extracellular regulated kinase 1/2 ETC: Electron transport chain FSH: Follicle-stimulating hormone GCLC: Glutamate-cysteine ligase subunit catalysis GPx: Glutathione peroxidase GSR: Glutathione reductase HCG: Human chorionic gonadotropin HO-1: Heme oxygenase 1 IGFBP1: Insulin-like growth factor-binding protein 1 IKK: Inhibitor of nuclear factor kappa-B kinase IUGR: Intrauterine growth restriction JNK: Jun N-terminal kinase Keap1: Kelch-like ECH-associated protein 1 MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemoattractant protein-1 MDA: Malondialdehyde MIF: Migration inhibitory factor MnSoD: Manganese superoxide dismutase NAC: N-acetylcysteine NADP(H): Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor-kappa B NQO1: NAD(P)H dehydrogenase (quinone 1) OS: Oxidative stress ox-LDL: Oxidized LDL PCOS: Polycystic ovary syndrome PGF 2 : Prostaglandin-F-2 PRL: Prolactin SO: Superoxide SOD: Superoxide dismutase TAS: Total antioxidant status TNF-: Tumor necrosis factor- uNK: Uterine natural killer VEGF: Vascular endothelial growth factor References Burton GJ, Jauniaux E

Stacking B12 with other evidence-based tools B12 is most effective as one component within a broader mood strategy