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Currently, the GLS1 inhibitor CB-839 is under phase 1 clinical evaluation in patients with advanced solid tumors (e.g., NCT02071862, NCT03875313, and NCT02861300), showing encouraging treatment effects, and further clinical trials are needed to establish its utility as a radiosensitizer [70, 76]

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[PubMed] [Google Scholar] 9.Bournat JC, Brown CW