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A significant fraction of the heme moeity may be converted to metabolites other than bilirubin, such as mesobilifuscins, that are excreted in the bile/feces and urine ( Heterozygote females are often considered only as carriers, leading to under-diagnosis of G6PD deficiency as the underlying cause of severe hyperbilirubinemia

Single-cell or spatial transcriptomic approaches would provide greater mechanistic resolution [33-34]

Treatment with rTFPI also significantly inhibited increases of TNF-, cytokine-induced neutrophil chemo-attractant, and myeloperoxidase in lung tissue

He sold his company, Braintree Venmo, to PayPal in 2013 for $800m the sort of money most people assume would fix everything in their lives but spent much of the following decade overeating, drinking too much and dealing with depression