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Seven days of L-citrulline supplementation at a daily dose of 2.4 g was shown to significantly increase plasma nitrite and nitrate, citrulline, and arginine

doi: 10.1002/ptr.7324 104 WuJJYangYWanYXiaJXuJFZhangLet al

We calculated ALS-FRS-R decline, as (48 - ALS-FRS-R at interview) divided by (time from disease onset to interview in month), as marker of disease progression

Research on short-term fluid restriction suggests plasma volume doesnt change dramatically under ordinary, everyday hydration swings
