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In human studies, lower antioxidant status, especially vitamin C, lycopene, vitamin E, and antioxidant enzymes superoxide dismutase and glutathione peroxidase, and high levels of markers of oxidative stress have been reported in the plasma [256,257,258,259] as well as cerebrospinal fluid [259,260,261] of AD patients

Yamamoto, M., Inohara, H
