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May 2019;98(19):e15566

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Clinical Trial Safety Data: Fosgonimeton Phase 2 The fosgonimeton Phase 2 Parkinson's disease trial provides one of the few systematic safety observations in a clinical population: Adverse Events in High-Dose Cohort 4 out of 10 patients in the high-dose fosgonimeton arm discontinued the trial due to adverse events This 40% discontinuation rate due to tolerability is concerning Specific adverse events reported included tremor exacerbation, increased hallucinations, and agitation While these effects might reflect exacerbation of Parkinson's disease symptoms rather than direct Dihexa-mechanism toxicity, they indicate that CNS-active angiotensin compounds are not benign in symptomatic neurological populations Implications for Dihexa Use Fosgonimeton is a related but distinct compound (intravenous, optimized formulation, different pharmacokinetics)