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These studies use subtherapeutic doses of a drug in a very small number of people (typically 10 to 15) to gather preliminary data on the agent's pharmacodynamics and pharmacokinetics before formal testing

Tarangelo, A

[DOI] [PubMed] [Google Scholar] 23.Xu C., Xiong Q., Tian X., Liu W., Sun B., Ru Q., Shu X

Results The volumetric glutathione production of recombinant strains individually overexpressing SER2 , SER1 , SER3 , and SER33 involved in l-Ser biosynthesis at 48 h cultivation was increased 1.3, 1.4, 1.9, and 1.9-fold, respectively, compared with that of the host GCI strain, which overexpresses genes involved in glutathione biosynthesis