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Accumulation of cisplatin in renal tubular cells induces various intracellular stresses, including DNA damage, mitochondrial pathology, oxidative stress and endoplasmic reticulum stress

Allergic reactions (rare), such as rash, itching, or swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing

A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

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