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EMBO J (1986) 5(10):250312

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Early warning signs Constant fatigue, even after a full nights sleep Weakness or lightheadedness Pale or jaundiced skin Mouth ulcers or a swollen, red tongue Numbness or tingling in the hands and feet These symptoms can be easy to dismiss or blamed on stress, poor sleep, or aging
But the titration assumes consistent subcutaneous absorption at each dose level
