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The excess oxidative stress in sepsis is produced by both an excess production of free radicals and a deficit in antioxidant defenses (scavengers)

The increase of fluorescence due to GSH conjugate was converted to the corresponding concentration of GSH in the reaction mixture since 1.0 fluorescence unit recorded on the chart had been calibrated to correspond to 0.1 M concentration of GSH conjugate

The stumbling block has always been that it has to be given IV, in a clinic licensed for administration of intravenous drugs, in order to be effective

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