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The data suggest that among the three major fatty acid metabolizing pathways in the arachidonic acid cascade (COX, LOX and CYP), oxylipins derived from the COX and CYP pathways are the most altered metabolites and showed ibuprofen-mediated sex-specific differences in male and female mice liver
The resulting solution was mixed by vortexing and then shaken gently for 2 min at 4C
Science 316 , 889894 (2007)

Integrative Med Clin J
