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Description
We showed that HSV-1 enhanced the Keap1-dependent ubiquitination and degradation of Nrf2, which resulted in substantial reductions in the expression levels of antioxidative genes, thereby disturbing cellular redox homeostasis and promoting ferroptosis
Its mechanism is direct lipolysis, making it a different tool with different patient profiles
The resulting peptides were desalted and concentrated before mass spectrometry by the STAGE-TIP method using a C18 resin disk (3 M Empore)
"Pharmaceuticals go for it," she said
