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doi: 10.1001/jamanetworkopen.2020.22398

Chemical constituents are the key material basis for revealing the efficacy of CHM ( Astragalus , can inhibit Schwann cell apoptosis, regulate nerve growth factor gene expression, increase NA + -K + -ATPase, inhibit erythrocyte aldose reductase activity, thereby inhibiting nerve injury, enhancing the speed of motor nerve conduction and minimizing the buildup of nerve and erythrocyte advanced glycation end products ( Wnt protein is an important signalling molecule

189,190 The invasive potential of these cells is driven by upregulated signaling pathways, including L1CAM, ephrin-B2, 191 and epithelialmesenchymal transition (EMT)-associated factors such as twist-related protein 1 (TWIST1), SOX2, and signal transducer and activator of transcription 3 (STAT3)